Cause of vitamin b12 deficiency
Cause of vitamin b12 deficiency are mainly divided into three categories:-

1-Nutritional

People are at risk of the deficiency of vitamin B12 having low protein diet. Body can store vitamin B12 up to 2 to 3year, if the absence of vitamin B12 is continue in the diet like liver, beef, cheese and shellfish then there is a chance for the development of vitamin B12.
A person who does not eat any animal product such as meat, milk, egg can suffer from vitamin B12 deficiency so they need a proper supplement of vitamin B12.
Deficiency of vitamin B12 is common in senior citizens because they take less nutritious diet and also take light meal.

2-Gastrointestinal

For the absorption of vitamin B12 gastric acid is extremely important, as vitamin B12 is drawn by gastric acid from protein. Senior citizens have a high risk of anemia and dementia and other illnesses by vitamin B12 deficiency because stomach acid production decreases with age.
Intestinal surgery and gastric bypass patients having a risk of development of nutritional deficiency. during these procedure gastric acid are lost in an excessive amount which are extremely important for the absorption vitamin B12.By the side effect of gastrointestinal surgery bacterial host are present within the intestinal wall which could result in low vitamin B12.
Antacid medication is very necessary for the the patient for proper absorption of vitamin B12 those who are suffering from chronic acid indigestion.Pregnant women should also take supplement of antacid with vitamin B12.
some genetic disorder are also cause irreparable disorder to the intestine which reduce the efficiency of nutrient absorption.patients suffering from celiac disease are sensitive to gluten they should the food containing gluten which could result in intestinal wall injury and malnourishment.Chonic diarrhea and undernourishment are the result of crohn’s disease which is a gastrointestinal condition ;symptoms of crohn’s disease include inflammation to the digestive tract.

3-Hereditary Mal absorption Syndrome

An extremely important antibody called “intrinsic factor” for the utilization of vitamin B12 ,it attach itself to the dietaryand assits in the absorption of vitamin B12.Those who are lacking with intrinsic factor whose presence is determined by heredity,cannot access vitamin B12 naturally from their food and risk becoming anemic.
Mostly sufferer are unaware of their condition of vitamin B12 deficiency untill they recive the blood test.

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Symptoms of vitamin B12 deficiency

To indicate the nutritional vitamin B12 deficiency there are many signs.For the proper analysis vitamin B12 blood screening is crucial.Symptoms include but not limited to:

Neurological symptom:

• Paresthesia
• Combined system disease
• Decrease reflexes
• Ataxia
• Peripheral neuropathy:abnormal gait,improved vibration or position sence,impaired pain or touch perception
• Increased unsteadiness on feet while eyes are closed,also known as Romberg’s sign
• Electric-like shocks down the spine while rotating the head,also known as Lhermitte’s sign
• Unexplained vision or taste impairment

Physical symptoms:

• Nausea
• Heartburn
• Weakness or fatigue
• Impotence
• Muscular soreness
• shortness of breath
• Abdominal blotting
• Headache
• Urinary and fecal incontinence
• Cardiovascular symptoms:
• Heart palpitations
• Increased like hood for heart attack and stroke

Psychological Symptom:

• Disorientation
• Memory loss
• Apathy
• Irritability
• Violent behavior
• Depression
• Paranoia
• Dementia
• Psychosis
• Personality changes
• Hallucinations

Hematological Symptoms:

• Megaloblastic anemia
• Pancytopenia

Pernicious anemia

This is a kind of metablastic anemia,documented in 1900s with the condition of insufficient heamoglobin in red blood cells and tissue.The symptoms of pernicious anemia is cheast pain,coldness in hand and feet,shortness of breath,dizziness headacheand extreme fatigue.

Sub-acute Combined Degeneration

SCD is a deterioration of the spinal cord caused by the deficiency of vitamin B12.SCD cause impairment to the peripheral nerve,eyes and brain.Its damage is irreversible if not detected earlier.symptoms vary between adults and children.

Test for vitamin B12 deficiency

Diagnosis of vitamin B12 deficiency can be obtain only through blood screening.chronic condition require screening in a month.For the prevention on deficiency yearly blood test is recommended.

sign of vitamin b12 deficiency

The person is at risk if belongs to the following group:

• People over the age of 60
• Vegetarian or vegans
• Individual with pernicious anemia
• Gastric bypass and gastrointestinal disorder patients
• Individual with chronic fatigue syndrome
• Autoimmune disease patients
• Athletes
• Crohn’s disease patients
• Chronic pancreatitis patients
• Thyroid disease patients
• Individual with malabsorption syndrome.

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Vitamin b12 is one of the important B-complex vitamins which required in the process of cell division and production of red blood cells. Vitamin b12 which is a water soluble vitamin works in the healthy nerve system development, cell development, blood cell development, manufacture of nerve-cell covering and maintenance of normal nervous system function. For normal synthesis of DNA vitamin b12 acts as co-enzyme. It also promotes normal fat and carbohydrate metabolism and protein synthesis.

Strict vegetarian are having the probability of vitamin b12 deficiency because all the good score of vitamin b12 is non-vegetarian food and milk product such as Beef, beef liver, blue cheese, clams, dairy products, eggs, flounder, herring, liverwurst, mackerel, milk, oysters, sardines, snappers and Swiss cheese. This vitamin is not available in plant foods. So vegetarian should take supplement with their meal for the fulfillment of vitamin b12 in their diet. If a person takes vitamin B complex supplement, he will find B12 vitamin in B complex vitamin supplement.

Some of the watchable vitamin b12 deficiency symptoms are fatigue, weakness in arm and legs, irreversible nerve damage, sore tongue nausea, appetite loss, weight loss, difficulty maintaining balance, pale lips, shortness of breath, depression, confusion.
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Person having above symptoms of vitamin b12 deficiency should take supplement of vitamin b12 as prescribed by doctors or should take vitamin b12 rich score in their diet. Vitamin B12 supplement can be used for treatment for nervous system disorder. It also improves nervous system to infection and disease. Vitamin b12 improves memory and ability to learn. A person having liver disease should not take heavy dose of vitamin b12 either it is supplement or dietary score.

Cobalamin known as vitamin b12 is responsible for the production of blood and maintaining brain and nervous system health. In the process of cell metabolism and in formation of DNA vitamin b12 is also needed. It is naturally found in liver, meat, milk products, eggs, cereal, barley, some algae, and bacteria. Since it contains cobalt, it is a red color. Liver can store half of the body’s B12 and can store years’ worth of B12.

By most statistics, maybe as many as 80% of aging baby boomers intend to work past the age of 65. It is not that most will not have the money they need to retire, most will, some more comfortably than others of course. So as baby boomers intend to push on in the work place and other areas of life, supplements such as vitamin B12 will play a big part in our lives.

Vitamin b12 contains cobalt which is very essential in the maintenance of nerve cells. As pertaining to the nervous system, vitamin B12 is essential to fatty acid metabolism. The nerves are protected by the layer of fatty acid as a sheath, called myelin sheath. This myelin sheath is maintained by the fatty acid and when improper synthesis occurs there is resulting damage and neuropathy. This is very long process and occurs by the lack of the absorption in the stomach.

Vitamin b12 helps in the production of DNA which in return helps the bone marrow to produce healthy red blood cells. Red blood cell contains a component called hemoglobin which is responsible for delivering oxygen to the tissue to the body. If the red blood cells are not healthy, then the tissues and organs of the body began to suffer in vitamin b12 deficiency. Sometime when body does not produce enough red blood cells and hemoglobin then it will result in anemia. Anemia caused by vitamin b12 deficiency is pernicious anemia. Gastric cells also play an important role in the deficiency of vitamin b12 by secreting insufficient amount of intrinsic factor which absorbs vitamin b12.

Homocysteine is very important amino acid which is helpful in such areas as depression, liver disorders and osteoarthritis, heart disease, stroke and bone weakness. All of these are of great importance to aging baby boomers. The malabsorption of the vitamin in aging baby boomers may very well be because of a lack of gastric juices produced by the body. Adequate absorption is usually accomplished when taken in the form of a dietary supplement.

Deficiency of vitamin b12 cause several diseases and chronic fatigue is one of the common vitamin b12 deficiency symptoms. Many patients suffering from chronic fatigue syndrome have found a certain amount of relief through the administration of vitamin B12 shots. Vitamin b12 is one of most important vitamin of B- complex which works to maintain the nervous system, skin, hair, eyes, mouth, and liver; as well as being involved in the formation of S-adenosylmethionine which is involved in mood and immune function.

Those patients who are suffering from chronic fatigue have increased level of homocysteine in the cerebrospinal fluid (CSF).There is a significant positive correlation between CSF homocysteine and B12 levels and fatigue-ability, as rated on the Comprehensive Psychopathological Rating Scale. It is concluded from a research that increased homocysteine levels in the central nervous system characterize patients fulfilling the criteria for fibromyalgia and chronic fatigue syndrome. Vitamin B12 deficiency can be considered a contributing factor to the higher homocysteine elevations found in the patients.

Administration of vitamin b12 shots as an integral part of any treatment for people suffering from chronic fatigue syndrome. Vitamin B12 is beneficial in so many patients with fatigue, regardless of the cause of their CFS.It is consider that high levels of nitric oxide tend to be responsible for many of the symptoms of chronic fatigue syndrome while vitamin B12 is a powerful nitric oxide scavenger. In a study it is consider that people deficient in vitamin b12 tends to worsen their symptoms of fatigue and mental ‘fogginess’ and ultimately leads to a weakened immune system.

To avoid the chronic fatigue syndrome it is very necessary to administrate vitamin b12 daily. Vitamin B12 deficiency is linked to high levels of homocysteine which lead to fatigue-ability and that the administration of vitamin B12 shots has been beneficial in treating many patients suffering from chronic fatigue syndrome.

To perform the vital functions in the body vitamins are very essential. Despite this many people do not consume enough of them on a daily basis which is largely down to poor dietary choices. There are different disease generate by the vitamin b12 deficiency.

1. BLOOD PROBLEMS: – A lack of vitamins can cause various type of anemia, in this condition lack of blood are happen in the body. Some diseases which are caused by vitamin b12 deficiency are:

• Macrocytic anemia – a condition where body produces fewer, larger red blood cells.
• Percinious anemia – a type of anemia that has similar characteristics to macrocytic anemia.
• Hemolytic anemia – a condition where your blood cells become very delicate and are destroyed faster than your body can produce them.

2. BONE PROBLEMS:- A deficiency in vitamin b12 can lead to various bone related problems. A vitamin D deficiency can cause rickets and osteomalacia (two conditions which cause your bones to become soft and bend, swell and fracture more easily).Not getting enough vitamin b12 can lead to osteoporosis (a condition where your bones density is reduced meaning that they are more likely to fracture).

3. SKIN PROBLEM: – A person having vitamin b12 deficiency can cause variety of skin problem. With the deficiency of vitamin b12 and some other vitamins skin become dry, greasy or scaly. Lips crack also happens by B12 deficiency. Not getting enough vitamins B7 and vitamin B12 can lead to the development of dry skin, rashes and even fungal infections. If a person do not consume enough vitamin b12 and other vitamin can cause age spots (brown pigmentations on the skin) to develop.

4. VISION PROBLEM: – A deficiency of some vitamin including vitamin b12 can cause damage to eyes which ultimately leads to problems with your vision. With the deficiency of vitamin A night blindness can occure.However if the deficiency of the vitamin b12 is untreated vision problem can develop into full blindness.

Without vitamins body cannot function properly and as a result cell production starts to suffer.vitamin b12 Deficiency then affects blood,bone,skin and more. To avoid the deficiency of vitamin b12 everyone should take a look on their diet. Diet should be full of vitamin b12.

Vitamin b12 is very responsible for brain and nervous system it also play an important role in blood production. Vitamin b12 is needed for metabolism and DNA health. Naturally founding scorce of vitamin b12 are liver, meat, milk product, eggs, cereals, barley, some algae and bacteria. Liver stores half of the body’s vitamin b12, which can store years’ worth of B12. It is recommended for adults to take 2 to 3 µg per day.

Absorption of vitamin b12 in the body takes place by the intrinsic factor and Pernicious anemia destroy stomach cells which produce intrinsic factor. This type of anemia may cause vitamin B12 deficiency.It is also hard to detect a B12 deficiency since these symptoms match many other causes such as aging and atherosclerosis. Homocysteine cause damage to arteries which can present in the body by vitamin b12 deficiency. There is a chance to heart disease, heart attacks, and strokes since clotting occurs to repair the arteries.

Irreversible deterioration of the spinal cord and nervous system is a result of lack of vitamin b12 in the body. Slight deficiency of vitamin b12 in the body can show the vitamin b12 deficiency symptoms of memory loss, depression with suicidal tendencies, mania, psychosis, paraphrenia complex which can develop into a wide range of mental diseases ranging from paranoia to schizophrenia, myelosis funicularis, and fatigue. Most of the time the damage is irreversible if the deficiency affects the brain in any way.

Antacids are also some factors which cause vitamin b12 deficiency by reducing the body’s ability to absorb B12.Those who have stomach, pancreas, and small intestine absorption issues may also be deficient in B12. Most of it is reabsorbed when it is used in digestion. In the treatment of anemia liver play a very good job, however iron seems to be a better way to treat anemia. Alzheimer’s disease and psoriasis, a skin rash are also prevented from vitamin b12.Some medicines have a risk of increasing B12 deficiency including antibiotics, cholesterol medication, anticonvulsants, and antacids for the stomach and other parts of the body. Alcohol and nicotine should not be used every day because it will affect the absorption of many vitamins including B12.

Vitamin b12 is one of the most important nutrients which should take in regular diet. This vitamin works to maintain nerves also in the formation of red blood cells. Deficiency of vitamin b12 is very common. Those who think that they take perfect diet might suffer from vitamin b12 deficiency. Strict vegetarian have more chance to become vitamin b12 deficient because good scorce of vitamin b12 are meat, egg, fish, milk and other dairy products.

There is two way to get vitamin b12 deficiency inadequate vitamin b12 intake and inadequate absorption from lack of stomach acid and loss of intrinsic factor .One can be vitamin b12 deficient and risk of disease increases because of elevated homocysteine.

Some early noticeable system of overt vtaminb12 B12 deficiency:

• Unusual fatigue
• Faulty digestion
• No appetite
• Nausea
• Loss of menstruation

Other vitamin b12 deficiency Symptoms :

• Nervousness
• Diarrhea
• Numbness and tingling of the hands and feet
• Striking behavioral change
• Mild depression
• Paranoia
• Fever
• Hyperactive reflexes
• Impotence
• Frequent upper respiratory infections
• Sore tongue
• Infertility
• Impaired memory
• Low platelet count and increased bleeding
• Neutropenia
• Macrocytic anemia

Neurological Symptoms

Neurological damage is not reversible if it is not detected earlier. This often referred to as subacute combined degeneration (SCD), are the biggest concern regarding B12 deficiency. The spinal cord and peripheral nerve are affected by SCD, and is normally different in children than adult.

B12 Deficiency Cause Nerve Damage

There are three main theories about nerve damage caused by vitamin b12 deficiency:

1. B12 deficiency produces a lack of methionine for conversion into S-adenosylmethionine (SAM).For the production of phosphatidylcholine (10) which is part of the myelin SAM is required.

2. The inability to convert methylmalonyl-CoA (a 3-carbon molecule) to succinyl-CoA (a 4-carbon molecule) results in an accumulation of propionyl-CoA (a 3-carbon molecule).By adding 2 carbons at a time to an even numbered carbon molecule fatty acids are normally made. In an overabundance of 3 carbon molecules, large amounts of unusual 15-carbon and 17-carbon fatty acids may be produced and incorporated into nerve sheets, causing altered nerve function.

3. Different hormone-like-molecule can damage nervous system such as cytokinin, tumour necrosis factor and epidermal growth factor which become unbalance in the nerve tissue in b12 deficiency.

Food contains all the possible nutrients we might ever require for a healthy living which we eat normally in a healthy fashion. It is not possible to maintain a balance of the entire nutrient which is required as a proper diet lack of some nutrients is always in the list which makes the deficiency of nutrients. And to overcome these deficiencies, we must take those nutrients in additional form. These additional nutrients are called supplement and the intake of these supplement should be first consulted with the doctor. Deficiency of different nutrients has different affects, the deficiency of some nutrients may go completely unnoticed and deficiency of some nutrients may cause serious repercussions. It is well known that vitamin b12 is associated with the functions of healthy nerve cells and it helps red blood cells in good shape and number. And also helps in the processing of DNA in our body. By vitamin b12 deficiency which leads malfunctioning in the body having lower number of red blood cells causes anemia. In this, the person suffers breathlessness (because of low oxygen supplied to the body). Dizziness, fatigue and low energy are basic vitamin b12 deficiency symptoms. Vitamin b12 deficiency also affects the gastrointestinal tract as well as its functioning. Its deficiency may cause nausea, vomiting, gas, either constipation or diarrhea as well. All of these lead to loosing appetite and weight.

The deficiency of vitamin b12 effects the health and functioning of these nerve cells because vitamin b12 helps in the healthy functioning of the nerve cell. The deficiency of this nutrient may lead to permanent damage of the nerve cells, if it is not diagnosed and treated on time. Numbness in the hands and feet, unable to balance, difficulty in walking, unusual depression and memory loss as well are the vitamin b12 deficiency symptoms.

Paleness on the skin and eyes, dryness of lips and similar symptoms, all attributing to low blood count shows vitamin b12 deficiency symptoms. Simply we can say that blood is the carrier of food and oxygen to all the parts of the body. If blood get affected (low red blood cells, in this case) it is bound to affect the entire body and the functions of all the organs. It is necessary that the vitamin b12 deficiency symptoms are identified at the earlier stage so that it can be controlled. We should take a proper balance diet having sufficient quantity of vitamin b12.Supplement should be also taken under doctor’s prescription.

Vitamin b12 is one of the essential vitamins which is good for health in many different way. It aids in helping the nervous system function properly, and also helps with blood cell production. There are various different types of score of vitamin b12 but the most common score are meat, fish, egg and dairy products. Though vitamin B12 deficiency can happen to anyone, strict vegetarians are often at risk because they don’t eat above mentioned score which are highly rich in vitamin b12.There are many different things that occur with a deficiency, and there appears to be a link between Candida and vitamin B12.

People who use to take alcohol heavily are at the risk of vitamin b12 deficiency disease. An intrinsic factor which is present in the body helps to absorb vitamin b12 in the stomach and intestines. The factor may have been affected or is missing if someone has had surgery in either area. Vitamin b12 cannot be absorbed as it should be when surgery is happens. Someone with this problem will have no appetite, bouts of loose stools, and they might feel very weak. The person might also affect from shortness of breath, problems with tingling numbness in the extremities and some mental fog. Disease such as anemia caused by vitamin b12 deficiency may be treated. This can be accomplished in a few different ways, but it is urgent that it happens quickly. This disease is very easy to treat which is a good news for patients who suffering from this disease. It is very easy to cure by in taking a proper vitamin b12 diet but it is not easy for strict vegetarians because a large source of vitamin b12 comes on non-vegetarian diet. Many times diet changes and a supplement of B12 will do the trick, and in some cases, shots might be needed rather than a pill. Some people refer injection to fight from vitamin b12 deficiency.

By the deficiency of vitamin b12 candida can be affected. Candida is a yeast that grows in body most notably it grow in intestine and in vaginal area. Candida is kept under control by the body immune system in most of the cases. However, when there is a lack of B12 the immune function is impaired and Candida can then grow out of control. When it happens than some problems that take place is headaches, tiredness, mental fog, mood swings, sinus issues loss of concentration and craving for sweet foods.

The deficiency of vitamin B12 will need to be taken care of first in order to treat Candida. When the proper balance of B12 is restored, the Candida can then be kept in check after a course of treatment and it has reverted back to its normal state with in the body. Now we can say that candida and vitamin b12 are related.

4 Negative vitamin b12 deficiency symptoms

Side effect of vitamin b12 is very rare in most of people, but there are side effect to some people.By the side effect of vitamin b12 some people react differently to ingestion which may be as a result of disease or genetically oriented differences.Some of the side effects that can expected from the use of vitamin b12 are swollen skin, hives itchy or skin rashes, these effects are normally visible after 10-20 minutes after ingesting vitamin b12.Side effects of vitamin b12 depending on factors such as weight and age.
Other vitamin B12 side effects that are associated with the consumption of vitamin B12 are Panic attacks, anxieties and insomnia.These side effects are mostly related to the functioning of the brain since the vitamin affects ones way of thinking. Upon the ingestion of vitamin b12 one can experience some side effects such as minor sharp chest pain, breathing  problems and palpitation  of the heart.The time that it takes for one to experience this differs from person to persons.
Vitamin B12 increases the energy levels, thus making one more involved in manual activities to dispose of the excess energy that arises from high metabolism levels.Contraction of muscles which make the movement uncomfortable is cause by the highly uptake of vitamin b12.Diarrhea is the most common disease which cause by uncomfortable digestive  vitamin b12.The degree of diarrhea will differ depending on one’s diet and reaction to the vitamin.Some people will experience stomach upsets and general uneasiness by the ingestion of vitamin b12.

Vitamin B12 Shots For Chronic Fatigue Syndrome